{"id":2780,"date":"2021-09-23T20:49:54","date_gmt":"2021-09-23T16:49:54","guid":{"rendered":"https:\/\/armanbegoyan.com\/?p=2780"},"modified":"2021-09-23T20:50:49","modified_gmt":"2021-09-23T16:50:49","slug":"treatment-resistant-depression","status":"publish","type":"post","link":"https:\/\/armanbegoyan.com\/hy\/2021\/09\/23\/treatment-resistant-depression\/","title":{"rendered":"\u054c\u0565\u0566\u056b\u057d\u057f\u0565\u0576\u057f \u0564\u0565\u057a\u0580\u0565\u057d\u056b\u0561"},"content":{"rendered":"<p>\u0540\u0578\u0563\u0565\u056f\u0561\u0576 \u0561\u057c\u0578\u0572\u057b\u0578\u0582\u0569\u0575\u0561\u0576 \u0578\u056c\u0578\u0580\u057f\u0578\u0582\u0574\u00a0 \u0574\u0565\u057b \u0564\u0565\u057c\u0587\u057d \u056f\u0561\u0576 \u0576\u0578\u0578\u0566\u0578\u056c\u0561\u0563\u056b\u0561\u056f\u0561\u0576 \u0574\u056b\u0561\u057e\u0578\u0580\u0576\u0565\u0580, \u0561\u0575\u056c \u056f\u0565\u0580\u057a \u0561\u057d\u0561\u056e\u055d 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\u0564\u0565\u057a\u0580\u0565\u057d\u056b\u057e \u056d\u0561\u0576\u0563\u0561\u0580\u0578\u0582\u0574\u0576\u0565\u0580\u056b \u0566\u0561\u0580\u0563\u0561\u0581\u0574\u0561\u0576 \u0574\u0565\u057b \u0574\u0565\u056e \u0576\u0565\u0580\u0564\u0580\u0578\u0582\u0574 \u056f\u0561\u0580\u0578\u0572 \u0567 \u0578\u0582\u0576\u0565\u0576\u0561\u056c \u056a\u0561\u057c\u0561\u0576\u0563\u0561\u056f\u0561\u0576 \u0576\u0561\u056d\u0561\u057f\u0580\u0561\u0574\u0561\u0564\u0580\u057e\u0561\u056e\u0578\u0582\u0569\u0575\u0578\u0582\u0576\u0568 (Fava &amp; Kendler, 2000)\u0589 \u053a\u0561\u0574\u0561\u0576\u0561\u056f\u0561\u056f\u056b\u0581 \u057f\u057e\u0575\u0561\u056c\u0576\u0565\u0580\u056b \u0570\u0561\u0574\u0561\u0571\u0561\u0575\u0576 \u0574\u0561\u0580\u0564\u056f\u0561\u0576\u0581 16%-\u0568 \u0563\u0565\u0569 \u0574\u0565\u056f \u0561\u0576\u0563\u0561\u0574 \u056f\u0575\u0561\u0576\u0584\u0578\u0582\u0574 \u0578\u0582\u0576\u0565\u0581\u0565\u056c \u0567 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\u0570\u0561\u056f\u0561\u0564\u0565\u057a\u0580\u0565\u057d\u0561\u0576\u057f\u0576\u0565\u0580\u056b \u0561\u057c\u0561\u057b\u056b\u0576 \u0576\u0577\u0561\u0576\u0561\u056f\u0578\u0582\u0574\u0568 \u0561\u0576\u0561\u0580\u0564\u0575\u0578\u0582\u0576\u0584 \u0567 \u056c\u056b\u0576\u0578\u0582\u0574\u055d \u0561\u0576\u056f\u0561\u056d \u0568\u0576\u057f\u0580\u057e\u0561\u056e \u057a\u0580\u0565\u057a\u0561\u0580\u0561\u057f\u056b\u0581 (Berlim &amp; Turecki, 2007), \u056b\u057d\u056f \u0561\u0575\u0581\u0565\u056c\u0578\u0582\u0576\u0565\u0580\u056b \u0574\u0575\u0578\u0582\u057d 1\/3-\u056b \u057a\u0561\u0580\u0561\u0563\u0561\u0575\u0578\u0582\u0574 \u0574\u056b\u0561\u0575\u0576 \u0574\u0561\u057d\u0561\u0574\u0562 \u0565\u0576 \u0561\u0566\u0564\u0578\u0582\u0574 \u0570\u0561\u056f\u0561\u0564\u0565\u057a\u0580\u0565\u057d\u0561\u0576\u057f\u0576\u0565\u0580\u0568\u055d \u0561\u0576\u056f\u0561\u056d \u0568\u0576\u057f\u0580\u057e\u0561\u056e 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20%-\u0568, \u0561\u0576\u056f\u0561\u056d \u0561\u057c\u056f\u0561 \u0568\u0576\u0569\u0561\u0581\u056b\u056f \u0562\u0578\u0582\u056a\u0574\u0561\u0576\u0568, \u0577\u0561\u0580\u0578\u0582\u0576\u0561\u056f\u0578\u0582\u0574 \u0565\u0576 \u0578\u0582\u0576\u0565\u0576\u0561\u056c \u0564\u0565\u057a\u0580\u0565\u057d\u056b\u0561\u055d \u0576\u0561\u0587 \u056d\u0561\u0576\u0563\u0561\u0580\u0574\u0561\u0576 \u0574\u0565\u056f\u0576\u0561\u0580\u056f\u056b\u0576 \u0570\u0561\u057b\u0578\u0580\u0564\u0578\u0572 \u0565\u0580\u056f\u0578\u0582 \u057f\u0561\u0580\u056b\u0576\u0565\u0580\u056b \u0568\u0576\u0569\u0561\u0581\u0584\u0578\u0582\u0574 (Fava, 2003)\u0589 \u0531\u0575\u057d \u057f\u0565\u057d\u0561\u0576\u056f\u0575\u0578\u0582\u0576\u056b\u0581 \u057d\u057f\u0561\u0581\u057e\u0578\u0582\u0574 \u0567, \u0578\u0580 \u0574\u0578\u057f\u0561\u057e\u0578\u0580\u0561\u057a\u0565\u057d \u0561\u0575\u0581\u0565\u056c\u0578\u0582\u0576\u0565\u0580\u056b 20-30%-\u056b 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\u0578\u0579 \u057c\u0565\u056f\u0578\u0582\u0580\u0565\u0576\u057f, \u0561\u0575\u057d\u056b\u0576\u0584\u0576 \u056f\u0580\u056f\u0576\u057e\u0578\u0572] \u0564\u0565\u057a\u0580\u0565\u057d\u056b\u057e \u056d\u0561\u0576\u0563\u0561\u0580\u0578\u0582\u0574\u0576\u0565\u0580\u056b \u056f\u0561\u0578\u0582\u0566\u0561\u056c \u00a0(\u057a\u0561\u057f\u0573\u0561\u057c\u0561\u0575\u056b\u0576) \u0562\u0578\u0582\u056a\u0578\u0582\u0574\u0568: \u0540\u0561\u0574\u0561\u0571\u0561\u0575\u0576 \u0574\u056b \u0577\u0561\u0580\u0584 \u0583\u0578\u0580\u0571\u0561\u0580\u0561\u0580\u0561\u056f\u0561\u0576 \u0587 \u0574\u0565\u057f\u0561-\u057e\u0565\u0580\u056c\u0578\u0582\u056e\u0561\u056f\u0561\u0576 \u0570\u0565\u057f\u0561\u0566\u0578\u057f\u0578\u0582\u0569\u0575\u0578\u0582\u0576\u0576\u0565\u0580\u056b, \u057c\u0565\u0566\u056b\u057d\u057f\u0565\u0576\u057f \u0564\u0565\u057a\u0580\u0565\u057d\u056b\u0561\u0575\u056b \u0562\u0578\u0582\u056a\u0574\u0561\u0576 \u0563\u0578\u0580\u056e\u0568\u0576\u0569\u0561\u0581\u0578\u0582\u0574 \u0577\u0561\u057f \u0562\u0561\u0580\u0571\u0580 \u0567, \u0574\u0561\u057d\u0576\u0561\u057e\u0578\u0580\u0561\u057a\u0565\u057d, \u056f\u0578\u0563\u0576\u056b\u057f\u056b\u057e-\u057e\u0561\u0580\u0584\u0561\u0562\u0561\u0576\u0561\u056f\u0561\u0576 \u0569\u0565\u0580\u0561\u057a\u056b\u0561\u0575\u056b \u0561\u0580\u0564\u0575\u0578\u0582\u0576\u0561\u057e\u0565\u057f\u0578\u0582\u0569\u0575\u0578\u0582\u0576\u0568 (\u0585\u0580\u055d Wiles et al., 2013; Nakagawa, 2017; Li et al., 2018; Zakhour et al., 2020):<\/p>\n<p>&nbsp;<\/p>\n<p><em><strong>\u0555\u0563\u057f\u0561\u0563\u0578\u0580\u056e\u057e\u0561\u056e \u0563\u0580\u0561\u056f\u0561\u0576\u0578\u0582\u0569\u0575\u0578\u0582\u0576<\/strong><\/em><\/p>\n<ul>\n<li>Berlim, M.T. &amp; Turecki, (2007). Definition, assessment, and staging of treatment-resistent refractory major depression: a review of current concepts and methods. <em>Can J Psychiatry<\/em>. 52(1): 46-54.<\/li>\n<li>Fava, M. (2003). Diagnosis and definition of treatment-resistant depression. <em>Biol Psychiatry<\/em>. 53(8): 649-659.<\/li>\n<li>Fava, M. &amp; Kendler, K.S. (2000). Major depressive disorder. <em>Neuron<\/em>. 28(2): 335-341.<\/li>\n<li>Kessler, D. et al. (2005). Screening for depression in primary care. <em>Br J Gen Pract<\/em>. 55(518): 659-660.<\/li>\n<li>Li, J. et al. (2018). Cognitive behavioral therapy for treatment-resistant depression: A systematic review and meta-analysis. <em>Psychiatry Res<\/em>., 268: 243-250.<\/li>\n<li>Nakagawa, A. (2017). Effectiveness of Suplementary Cognitive-Behavioral Therapy for Pharmacology-Resistant Depression: A Randomized Controlled Trial. <em>J Clin Psychiatry<\/em>, 78(8): 1126-1135.<\/li>\n<li>Wiles, N. et al. (2013). Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomized controlled trial. <em>Lancet<\/em>, 381(9864): 375-384.<\/li>\n<li>Zakhour, S. et al. (2020). Cognitive-behavioral therapy for treatment-resistant depression in adults and adolescents: a systematic review. <em>Trends Psychiatry Psychother<\/em>., 42(1): 92-101.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u0540\u0578\u0563\u0565\u056f\u0561\u0576 \u0561\u057c\u0578\u0572\u057b\u0578\u0582\u0569\u0575\u0561\u0576 \u0578\u056c\u0578\u0580\u057f\u0578\u0582\u0574\u00a0 \u0574\u0565\u057b \u0564\u0565\u057c\u0587\u057d \u056f\u0561\u0576 \u0576\u0578\u0578\u0566\u0578\u056c\u0561\u0563\u056b\u0561\u056f\u0561\u0576 \u0574\u056b\u0561\u057e\u0578\u0580\u0576\u0565\u0580, \u0561\u0575\u056c \u056f\u0565\u0580\u057a \u0561\u057d\u0561\u056e\u055d \u056d\u0561\u0576\u0563\u0561\u0580\u0578\u0582\u0574\u0576\u0565\u0580, \u0578\u0580\u0578\u0576\u0581 \u0564\u0561\u057d\u0561\u056f\u0561\u0580\u0563\u0578\u0582\u0574\u0568 \u0564\u0565\u057c\u0587\u057d \u0561\u0576\u0578\u0580\u0578\u0577 \u0567, \u056b\u057d\u056f \u0569\u0565\u0580\u0561\u057a\u0587\u057f\u056b\u056f \u0574\u0578\u057f\u0565\u0581\u0578\u0582\u0574\u0568 \u0564\u0580\u0561\u0576\u0581\u055d \u057e\u056b\u0573\u0565\u056c\u056b\u0589 \u0534\u0580\u0561\u0576\u0581\u056b\u0581 \u0574\u0565\u056f\u0576 \u0567` \u057c\u0565\u0566\u056b\u057d\u057f\u0565\u0576\u057f \u056f\u0561\u0574 \u0564\u0565\u0572\u0561\u056f\u0561\u0575\u0578\u0582\u0576 \u0564\u0565\u057a\u0580\u0565\u057d\u056b\u0561\u0576 (Treatment Resistant Depression), \u0561\u0575\u057d\u056b\u0576\u0584\u0576 \u0564\u0565\u057a\u0580\u0565\u057d\u056b\u057e \u056d\u0561\u0576\u0563\u0561\u0580\u0578\u0582\u0574, \u0578\u0580\u0568 \u0579\u056b \u057f\u0580\u057e\u0578\u0582\u0574 \u056f\u0561\u0574 \u0574\u0561\u057d\u0561\u0574\u0562<\/p>\n","protected":false},"author":2,"featured_media":2781,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,207,148,18],"tags":[119,237],"class_list":["post-2780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-psychology","category-cognitive-behavioural-therapy","category-counseling","category-psychotherapy","tag-depression","tag-treatment-resistant-depression"],"_links":{"self":[{"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/posts\/2780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/comments?post=2780"}],"version-history":[{"count":3,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/posts\/2780\/revisions"}],"predecessor-version":[{"id":2784,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/posts\/2780\/revisions\/2784"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/media\/2781"}],"wp:attachment":[{"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/media?parent=2780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/categories?post=2780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/armanbegoyan.com\/hy\/wp-json\/wp\/v2\/tags?post=2780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}